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Test Name

Antinuclear Antibody Comprehensive Panel 1

CPT Code(s)

86038, 86225, 86235 (x5), 86431


Antinuclear Antibody EIA Screen with Reflex to IFA Titer
Rheumatoid Factor
DNA (DS) Antibodies
Sm and Sm/RNP Antibodies
Scleroderma Antibodies (SCL-70)
Sjögren's Antibodies (SSA,SSB)


Enzyme Immunoassay (EIA) • Immunofluorescence Assay (IFA) • Immunoturbidimetry

Reference Range(s)

ANA Screen Negative
Antinuclear Antibodies
<1:40 Negative
1:40 - 1:80 Low antibody level
>1:80 Elevated antibody level

Rheumatoid Factor
<14 IU/mL

DNA (ds) Antibodies

IU/mL Interpretation
<30 IU/mL Negative
30-60 IU/mL Low Positive
61-200 IU/mL Positive
>200 IU/mL Strong Positive
SM Antibody Index  
≤1.00 Negative
>1.00 Positive
SM/RNP Antibody Index  
≤1.00 Negative 
>1.00 Positive 

Scleroderma Antibodies (Index)

≤1.00   Negative
>1.00 Positive

Sjögrens Antibodies (SSA)
≤1.00 Negative
>1.00 Positive
Sjögrens Antibodies (SSB)
≤1.00 Negative
>1.00 Positive

To view specimen requirements and codes please Select a regional laboratory.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

Antinuclear Antibody Comprehensive Panel 1