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Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
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CPT Code(s)
86200
Methodology
Immunoassay (IA)
Limitations
The presence of immune complexes may cause false-positive results due to increased non-specific binding.
Reference Range(s)
| Negative | <20 Units | ||||
| Weak positive | 20-39 Units | ||||
| Moderate positive | 40-59 Units | ||||
| Strong positive | >59 Units | ||||
Clinical Significance
A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from patients with other diseases such as hepatitis C infection. Rheumatoid Arthritis Classification Criteria include CCP IgG Antibody, rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate (ESR). Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.
Alternative Name(s)
Citrullinated Peptide (CCP) IgG,CCP,Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
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