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Test Name

Cyclic Citrullinated Peptide (CCP) Antibody (IgG)

CPT Code(s)

86200

Methodology

Immunoassay (IA)

Limitations

The presence of immune complexes may cause false-positive results due to increased non-specific binding.

Reference Range(s)

Negative <20 units
Weak positive 20-39 units
Moderate positive 40-59 units
Strong positive >59 units

Clinical Significance

A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

Alternative Name(s)

Citrullinated Peptide (CCP) IgG,CCP,Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

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Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
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