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Serotonin, Blood [818X]

Test Code


CPT Code(s)


Patient Preparation

Patient should avoid food high in indoles such as avocado, banana, tomato, plum, walnut, pineapple, and eggplant. Patient should also avoid tobacco, tea and coffee three days prior to specimen collection.

Preferred Specimen(s)

4 mL whole blood collected in an EDTA (lavender-top) tube - (see instructions)

Minimum Volume

1 mL

Collection Instructions

Serotonin Kit (provided by Quest Diagnostics Chantilly):
Draw one 4 mL (lavender-top) tube, and transfer immediately to a plastic bottle containing 35 mg Ascorbic Acid. Mix well, freeze -20ºC or colder, and send frozen samples on dry ice.

Transport Temperature


Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 42 days

Reject Criteria

Received room temperature • Received refrigerated


High Performance Liquid Chromatography (HPLC) • Fluorescence Detection

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 2 days

Reference Range(s)

56-244 ng/mL

Clinical Significance

Serotonin is produced in excess by carcinoid tumors of the enterochromaffin cell usually in the small intestine, appendix or rectum.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
9651Serotonin, Blood2939-7Serotonin

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.