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GLUTATHIONE

Test Code

90379X

CPT Code(s)

82978

Preferred Specimen(s)

10 mL (1 mL minimum) Whole blood collected in an ACD
(yellow-top) tube

Transport temperature: Refrigerated
Transport Container: ACD (yellow-top) tube

Minimum Volume

1 mL

Specimen Stability

Room temperature: Unacceptable
Refrigerated (cold packs): 21 days
Frozen: Unacceptable

Methodology

Kinetic

Performing Laboratory

Cambridge Biomedical

Setup Days

Set up: Varies; Report available: 3 days

Report Available

3 days

Reference Range(s)

544-1228 uM

Clinical Significance

Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced
condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as Parkinson’s disease. High levels of glutathione have been linked to chemotherapy resistance in cancer treatments.

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.