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AccuType® IL28B

Test Code


CPT Code(s)

This test is for non-New York patient testing. For New York testing, please see Test Code 90252.

Patient Preparation

Do not eat immediately prior to sample collection. If patient has eaten recently, rinse mouth with plain water.

Preferred Specimen(s)

5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

2 mL

Alternative Specimen(s)

Whole blood collected in: ACD solution A or B (yellow-top) tube • Buccal swab collected in: DNA Genotek Oracollect Kit, or Celera DNA Collection Kit (follow collection kit instructions)

Collection Instructions

Do not freeze whole blood.

Buccal Swab: Use only Celera/Copan DNA Collection Kit (Celera part # is 5002737) or DNA Genotek OraCollect Kit (OC-100). Follow collection kit instructions.

Transport Temperature

Room temperature

Specimen Stability

Whole blood
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Buccal swab
Room temperature: 14 days
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria

Received frozen • Buccal swab received refrigerated • Incorrect collection device • Liquid has leaked from container/no liquid present


Real-Time Polymerase Chain Reaction

Performing Laboratory

Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

Setup Schedule

Set up: Daily night; Report available: 3 days

Reference Range(s)

See Laboratory Report

Clinical Significance

The C polymorphism in rs12979860 is strongly associated with a two fold greater sustained virological response in European, African American, and Hispanic populations. Knowledge of the host genotype of patients infected with HCV will aid in the clinical decision to initiate treatment with PegIFN and RBV (a 48 week course of interferon and ribavirin which has limited efficacy and is often poorly tolerated due to side effects that prevent patients from finishing treatment).

Alternative Name(s)

Pegylated Interferon, Ribavirin, IL28 Polymorphism (rs12979860), Interleukin 28B, Hepatitis C (HCV), IL28B

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
90251AccuType(R) IL28BPending assignment
ASTMRCVDResults Received19146-0Reference lab test results

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.