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Vitamin B12 (Cobalamin) and Folate Panel, Serum

Test Code


CPT Code(s)

82607, 82746

Preferred Specimen(s)

2 mL serum - protect from light

Minimum Volume

1 mL

Collection Instructions

Note: Send serum in an amber tube. If amber tube is not available, wrap tube in aluminum foil to protect from light.

Transport Container

Serum Separator Tube (SST®)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Rrefrigerated: 7 days
Frozen: 21 days

Reject Criteria



Immunoassay (IA)

Setup Schedule

Set up: Daily; Report available: 1 day

Reference Range(s)

See individual analytes

Clinical Significance

Folic acid deficiency is common in pregnant women, alcoholics, patients with diets that do not include raw fruits and vegetables, and people with structural damage to the small intestine. The most reliable and direct method of diagnosing folate deficiency is the determination of folate levels in both erythrocytes and serum. Low folic acid levels, however, can also be the result of a primary Vitamin B12 deficiency that decreases the ability of cells to take up folic acid. Vitamin B12 is decreased in pernicious anemia, total or partial gastrectomy, malabsorption and certain congenital biochemical disorders.

Alternative Name(s)

Vitamin B12/Folic Acid

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
B12Vitamin B122132-9Cobalamins
FOLATEFolate, Serum2284-8Folate

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.