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RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing (REFL)

Test Code


CPT Code(s)



If RPR Screen is reactive, RPR Titer and Fluorescent Treponemal Antibody (FTA) confirmation will be performed at an additional charge (CPT code(s): 86593, 86780).

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.6 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic



Performing Laboratory

Quest Diagnostics - West Region

Setup Schedule

Set up: Tues-Sat (Day and Night shifts; cutoff: 12 a.m.); Report available: 3 days

Reference Range(s)


Clinical Significance

The RPR is a screening test for syphilis. False positive results may occur due to systemic lupus erythematosis, malaria, mononucleosis, infectious hepatitis, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Positive results should be confirmed with the more specific FTA-ABS.
A reactive FTA-ABS test confirms the presence of treponemal antibodies but does not indicate the stage or presence of active infection. The FTA-ABS does not distinguish between syphilis and other treponemal infections. Once the FTA-ABS becomes positive, it remains so for long periods, regardless of therapy. False positive reactions have been associated with diseases with increased or abnormal globulins, patients with lupus erythromatosis positive Anti-Nuclear Antibodies (ANA) and during pregnancy.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.