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Lyme Disease Antibody with Reflex to Blot (IgG, IgM)

Test Code

6646

CPT Code(s)

86618

Includes

If Lyme Ab Screen is ≥0.90 then the Lyme Disease Antibodies (IgG, IgM) by Immunoblot will be performed at an additional charge (CPT code(s): 86617 (x2)).

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.7 mL

Specimen Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Tues-Sat a.m.; Report available: Next day

Reference Range(s)

Lyme Antibody Screen

Index Interpretation
<0.90 Negative
0.90-1.09 Equivocal
>1.09 Positive

As recommended by the Food and Drug Administration (FDA), all samples with positive or equivocal results in a Borrelia burgdorferi antibody screen will be tested using a blot method. Positive or equivocal screening test results should not be interpreted as truly positive until verified as such using a supplemental assay (e.g., B. burgdorferi blot).

The screening test and/or blot for B. burgdorferi antibodies may be falsely negative in early stages of Lyme disease, including the period when erythema migrans is apparent.

Clinical Significance

Lyme disease is caused by a bacterium Borrelia burgdorferi and is transmitted by ticks. A screening test with high sensitivity is used as the first step in the CDC recommended algorithm. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected screening result.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
26102BLyme Ab Screen5060-9Borrelia burgdorferi Ab
2976AProgressive Lyme20449-5Borrelia burgdorferi Ab

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.