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Herpes Simplex Virus 1/2 IgG, Type-Specific Antibodies (HerpeSelect®)

Test Code

6447N

CPT Code(s)

86695, 86696

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.2 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Gross lipemia • Heat inactivated serum

Methodology

Immunoassay (IA)

Performing Laboratory

Focus Diagnostics, Inc.
5785 Corporate Ave.
Cypress, CA 90630-4726

Setup Schedule

Set up: Tues-Sat; Report available: 2-5 days

Limitations

Individuals infected with HSV may not exhibit detectable IgG antibody in the early stages of infection.

Reference Range(s)

<0.90 Negative
0.90-1.10 Equivocal
>1.10 Positive

Clinical Significance

Herpes Simplex Virus (HSV) is responsible for several clinically significant human viral diseases, with severity ranging from inapparent to fatal. Clinical manifestations include genital tract infections, neonatal herpes, meningoencephalitis, keratoconjunctivitis, and gingivostomatitis. There are two HSV serotypes that are closely related antigenically. HSV type 2 is more commonly associated with genital tract and neonatal infections, while HSV type 1 is more commonly associated with infections of non-genital sites. Specific typing is not usually required for diagnosis or treatment. The mean time to seroconversion using the type specific assay is 25 days. The performance of this assay has not been established for use in a pediatric population, for neonatal screening, or for testing of immunocompromised patients.

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.