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Epstein-Barr Virus Antibody Panel

Test Code

6421

CPT Code(s)

86664, 86665 (x2)

Includes

Epstein-Barr Virus VCA Antibody (IgM), Epstein-Barr Virus VCA Antibody (IgG), Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.6 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Gross lipemia • Icteric

Methodology

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics-Atlanta
1777 Montreal Circle
Tucker, GA 30084-6802

Setup Schedule

Set up: Mon-Fri 7 a.m.(Estimated Report time 5 p.m.); Report available: 3 days

Reference Range(s)

Epstein-Barr Virus VCA Antibody (IgM)

≤0.90 Negative
0.91-1.09 Equivocal
≥1.10 Positive
Epstein-Barr Virus VCA Antibody (IgG)
≤0.90 Negative
0.91-1.09 Equivocal
≥1.10 Positive
Epstein-Barr Virus Nuclear Antigen (EBNA ) Antibody (IgG)
≤0.90 Negative
0.91-1.09 Equivocal
≥1.10 Positive

Clinical Significance

Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. VCA-IgM is typically detectable at clinical presentation, then declines to undetectable levels within a month in young children and within 3 months in other individuals. VCA-IgG is typically detectable at clinical presentation, and persists for life. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life.

Alternative Name(s)

EBV

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
70030200EBV VIRAL CAPSID AG (VCA) AB (IGM)5159-9Epstein Barr virus capsid Ab.IgM
70030300EBV VIRAL CAPSID AG (VCA) AB (IGG)5157-3Epstein Barr virus capsid Ab.IgG
70030700EBV NUCLEAR AG (EBNA) AB (IGG)30083-0Epstein Barr virus nuclear Ab.IgG

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.