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Histamine, 24-Hour Urine

Test Code


CPT Code(s)




Patient Preparation

Patient should avoid direct sunlight. Patient should avoid taking antihistamines, oral corticosteroids and substances which block H2 receptors for at least 24 hours prior to specimen collection.

Preferred Specimen(s)

4 mL urine from a 24-hour collection containing 10 mL 6N HCl

See Urine in the Blood, Urine and Stool section of Specimen Collection and Handling

If multiple 24-Hour tests will be ordered, see 24-Hour Urine Collection: Requirements for Multiple Tests in Specimen Collection and Handling.

Minimum Volume

2 mL

Alternative Specimen(s)

Urine with no preservative

Collection Instructions

Write total 24-hour volume on the container and the test requisition

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 14 days
Frozen: 14 days

Reject Criteria

Moderate or gross hemolysis


Immunoassay (IA)

This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

Setup Schedule

Set up: Tues, Thurs, Sat a.m.; Report available: 8 days

Reference Range(s)

Histamine, 24-Hour Urine 0.006-0.131 mg/24 h
Creatinine, 24-Hour Urine
3-8 Years 0.11-0.68 g/24 h
9-12 Years 0.17-1.41 g/24 h
13-17 Years 0.29-1.87 g/24 h
Adult 0.63-2.50 g/24 h

Clinical Significance

Histamine is a mediator of the allergic response. Histamine release causes itching, flushing, hives, vomiting, syncope, and even shock. In addition, some patients with gastric carcinoids may exhibit high concentrations of histamine.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
85986150TOTAL VOLUME3167-4Specimen volume
85986151HISTAMINE, 24 HR URINE9410-2Histamine
85986152CREATININE, URINE2162-6Creatinine

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.