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N-Methyl Histamine, Urine [10243X]

Test Code


CPT Code(s)

82570, 83789



Preferred Specimen(s)

5 mL of a well mixed, unpreserved 24-hour urine

Minimum Volume

3 mL

Alternative Specimen(s)

Unpreserved urine • Preserved 24-hour urine with (30 mL 6N HCI, or 25 mL of 50% Acetic Acid, or 5 grams Na2CO3, or 10 grams of Boric Acid during collection)

Collection Instructions

Collect 24-hour urine with no preservatives.
Icteric specimens are no longer rejected. Total volume is required. Record on both the specimen container and the request form.

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection: 6N HCl, 50% Acetic Acid, Na(2)CO(3), Toluene, 6N HNO(3), Boric Acid, Thymol.

Specimen Container

Plastic Urine Container, leak-proof

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 8 days
Frozen: 14 days


Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) • Enzymatic Colorimetric Assay

Performing Laboratory

Mayo Medical Laboratories
200 First Street SW
Rochester, MN 55905

Setup Schedule

Set up: Tues, Thurs a.m.; Report available: 5 days

Reference Range(s)

N-Methylhistamine, Urine
0-5 years: 120-510 mcg/g creatinine
6-16 years: 70-330 mcg/g creatinine
>16 years: 30-200 mcg/g creatinine

Clinical Significance

Screening for and monitoring of mastocytosis and
disorders of systemic mast-cell activation, such as
anaphylaxis and other forms of severe systemic allergic
reactions. Monitoring therapeutic progress in conditions
that are associated with secondary, localized, low-grade
persistent, mast-cell proliferation and activation such
as interstitial cystitis.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
49317N-Methyl Histamine, Urine12714-2N-methylhistamine
ASTMRCVDResults Received19146-0Reference lab test results
AVOLUMEURINE VOLUME3167-4Specimen volume

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.