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Varicella-Zoster Virus Antibody (IgG)

Test Code

4439

CPT Code(s)

86787

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.1 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days

Reject Criteria

Gross hemolysis • Gross lipemia • Grossly icteric

Methodology

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics-Tampa
4225 E Fowler Avenue
Tampa, FL 33617-2026

Setup Schedule

Set up: Mon-Fri (Day shift); Report available: 3 days

Limitations

Other herpes viruses may cross react and produce high titers. Protection may be limited at low positive titers. Antibodies persist after infection has been treated or becomes dormant.

Reference Range(s)

VZV Ab (IgG) ≤0.90
Interpretive criteria
≤0.90 Negative - Antibody not detected
0.91-1.09 Equivocal
≥1.10 Positive - Antibody detected
A positive result indicates that the patient has antibody to VZV but does not differentiate between an active or past infection. The clinical diagnosis must be interpreted in conjunction with the clinical signs and symptoms of the patient. This assay reliably measures immunity due to previous infection but may not be sensitive enough to detect antibodies induced by vaccination. Thus, a negative result in a vaccinated individual does not necessarily indicate susceptibility to VZV infection.

Clinical Significance

Varicella-Zoster Virus (VZV) causes chicken pox and when reactivated, potentially decades later, causes shingles. Twenty percent of adults will develop shingles, a rash or blister of the skin that may cause severe pain. Varicella-Zoster IgG, EIA reliably measures immunity due to previous infection, but is unsuitable for detection of post-vaccination immune status.

Alternative Name(s)

Herpes Zoster, Shingles, Chicken Pox

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
70011500VARICELLA ZOSTER VIRUS ANTIBODY (IGG)5403-1Varicella zoster virus Ab.IgG

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.