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Estradiol

Test Code

4021

CPT Code(s)

82670

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Note: For any patients for whom low estradiol levels are anticipated (e.g. males, pre-pubertal children and hypogonadal/post-menopausal females), the Quest Diagnostics Estradiol, Ultrasensitive, LC/MS/MS assay is recommended (test code 30289).

Note: Do not add on estradiol testing to a barrier gel specimen older than 72 hours. Estradiol binds to barrier gel causing decreased values.

Transport Container

Serum Separator Tube (SST®)

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 6 months
*Do not add estradiol testing to a barrier gel specimen older than 72 hours

Reject Criteria

Serum stored on barrier gel for more than 72 hours

Methodology

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics-Horsham
900 Business Center Drive
Horsham, PA 19044-3408

Setup Schedule

Set up: Mon-Fri (Day shift)

Reference Range(s)

Female  
  Follicular Phase 19-144 pg/mL
  Mid-Cycle 64-357 pg/mL
  Luteal Phase 56-214 pg/mL
  Postmenopausal ≤31 pg/mL
Male ≤39 pg/mL

Clinical Significance

Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
55006500ESTRADIOL2243-4Estradiol

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.