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Hemoglobinopathy Evaluation

Test Code

35489

CPT Code(s)

83021, 85014, 85018, 85041

Includes

Hemoglobin A1, Fetal Hemoglobin, Hemoglobin A2 and any hemoglobin variants, Red Blood Cell Count, Hemoglobin, Hematocrit, MCV, MCH, RDW

Preferred Specimen(s)

Whole blood from a full EDTA (lavender-top) tube

Collection Instructions

Patient age and ethnicity are necessary for proper interpretation. Blood transfusions within the last 4 months may affect results.

Transport Container

EDTA (lavender-top) tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: 6 days
Frozen: Unacceptable

Reject Criteria

Frozen whole blood

Methodology

High Performance Liquid Chromatography (HPLC) followed by, if necessary, Alkaline and Acid Hemoglobin Electrophoresis on Agarose Gel

Performing Laboratory

Quest Diagnostics-Chicago
1355 Mittel Blvd
Wood Dale, IL 60191-1024

Reference Range(s)

See Laboratory Report

Clinical Significance

The detection and proper identification of hemoglobinopathies and thalassemias is an important aspect of the evaluation of patients with anemia, microcytosis and erythrocytosis.

Alternative Name(s)

Hemoglobin Electrophoresis, HGB Variants, HB S, Hemoglobin F, HGB Evaluation, Hemoglobin S, HB A2, HGB Electrophoresis, Hemoglobin Variants, Hemoglobin A2, Thalassemia Screen, HB F

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
30000100RED BLOOD CELL COUNT789-8Erythrocytes
30000200HEMOGLOBIN718-7Hemoglobin
30000300HEMATOCRIT4544-3Hematocrit
30000400MCV787-2Erythrocyte mean corpuscular volume
30000500MCH785-6Erythrocyte mean corpuscular hemoglobin
30000700RDW788-0Erythrocyte distribution width
50053920HEMOGLOBIN A4546-8Hemoglobin A/Hemoglobin.total
50054340HEMOGLOBIN S4625-0Hemoglobin S/Hemoglobin.total
50054350HEMOGLOBIN C4563-3Hemoglobin C/Hemoglobin.total
50054355OTHER HEMOGLOBIN 142248-5Hemoglobin.other/Hemoglobin.total
50054360HEMOGLOBIN E4575-7Hemoglobin E/Hemoglobin.total
50054365OTHER HEMOGLOBIN 242248-5Hemoglobin.other/Hemoglobin.total
50054370INTERPRETATION12710-0Hemoglobin pattern
50062100HEMOGLOBIN A2 (QUANT)4551-8Hemoglobin A2/Hemoglobin.total
50062300HEMOGLOBIN F4576-5Hemoglobin F/Hemoglobin.total

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.