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Methylmalonic Acid

Test Code


CPT Code(s)


Preferred Specimen(s)

2 mL serum

Minimum Volume

0.6 mL

Alternative Specimen(s)

Serum collected in: No additive (dark blue-top) tube • Plasma collected in: Sodium heparin (green-top) tube

Collection Instructions

Serum collected in dark/royal blue, trace metal-free tube is acceptable.

Red-top tubes (preferred): Centrifuge the specimen as soon as possible after complete clot formation has taken place. Transfer the serum to a plastic screw-capped vial.

Barrier gel separator tubes (acceptable): Centrifuge the specimen as soon as possible after complete clot formation has taken place. Do not place barrier tubes in an ice bath as freezing may prevent the barrier gel from adequately separating serum from cells. Transfer the serum to a plastic screw-capped vial.

Heparin tubes (acceptable): Centrifuge the specimen as soon as possible (within one hour after collection) and transfer the plasma to a plastic screw-capped vial.

Dark/royal blue-top serum tube and Dark/royal blue-top sodium heparin tube are acceptable containers. Instructions for collecting blood in dark/royal blue-top serum tube is similar to red-top or SS tubes and sodium heparin tubes.

Specimen Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 10 months


Tandem Mass Spectrometry

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Mon-Sat a.m.; Report available: 2 days

Reference Range(s)

87-318 nmol/L

Clinical Significance

Test is useful in the determination of certain genetic disorders and Vitamin B12 deficiency.

Alternative Name(s)


LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
3493AMethylmalonic Acid13964-2Methylmalonate

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.