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Glutamic Acid Decarboxylase-65 Antibody
Test Code
34878
CPT Code(s)
86341
Preferred Specimen(s)
1 mL serum
Minimum Volume
0.2 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months
Reject Criteria
Received room temperature
Methodology
Radiobinding Assay
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
Setup Schedule
Set up: Sun, Tues, Thurs; Report Available: 5-6 days
Limitations
GAD-65 antibodies are detected in 20% of diabetic twins who remain disease-free for long periods of time and in 8% of healthy individuals.
Reference Range(s)
≤1.0 U/mL
Clinical Significance
Glutamic Acid Decarboxylase (GAD-65) Antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess risk for development of IDDM, to predict onset of IDDM, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin autoantibody (IAA).
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
(The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.)
* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.