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IGF Binding Protein-3 (IGFBP-3)

Test Code

34458

CPT Code(s)

83519

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days

Refrigerated: 14 days

Frozen: 1 year

Reject Criteria

Gross hemolysis • Gross lipemia • Plasma • Specimens out of stability

Methodology

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics Nichols Institute

33608 Ortega Highway

San Juan Capistrano, CA 92690-6130

Setup Schedule

Set up: Mon-Fri; Report available: 3-6 days

Reference Range(s)

IGF-Binding Protein-3 (mg/L) Age Units
  1-7 days <0.7
  8-15 days  0.5-1.4
  16 days-1 year 0.7-3.6
  2 years 0.8-3.9
  3 years 0.9-4.3
  4 years 1.0-4.7
  5 years 1.1-5.2
  6 years 1.3-5.6
  7 years 1.4-6.1
  8 years 1.6-6.5
  9 years 1.8-7.1
  10 years 2.1-7.7
  11 years 2.4-8.4
  12 years 2.7-8.9
  13 years 3.1-9.5
  14 years  3.3-10.0
  15 years 3.5-10.0
  16 years 3.4-9.5
  17 years 3.2-8.7
  18 years 3.1-7.9
  19 years  2.9-7.3
  20 years 2.9-7.2
  21-30 years 3.4-7.8
  31-40 years 3.4-7.0
  41-50 years 3.3-6.7
  51-60 years 3.4-6.9
  61-70 years  3.0-6.6
  71-80 years 2.5-5.7
  81-85 years 2.2-4.5
  >85 years No primary data
Protein-3 (IGFBP-3) by Pubertal (Tanner) Stage (mg/L):    
Females Tanner I 1.2-6.4
  Tanner II 2.8-6.9
  Tanner III 3.9-9.4
  Tanner IV 3.3-8.1
  Tanner V 2.7-9.1
Males Tanner I 1.4-5.2
  Tanner II 2.3-6.3
  Tanner III  3.1-8.9
  Tanner IV 3.7-8.7
  Tanner V  
                

Clinical Significance

Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the six distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.

IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in cromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Thus, both assays and the ratios of IGF-I/IGFBP-2 and IGFBP-2/IGFBP-3 are useful as markers of GH action and for discriminating between growth hormone deficiency and short stature due to other etiologies in children. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes.

The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

(The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.)

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.