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Lyme Disease Antibody Index for CNS Infection

Test Code

34194

CPT Code(s)

82040, 82042, 82784 (X2), 86618 (X4)

Includes

Borrelia burgdorferi IgG, IgM Antibodies (CSF and Serum); Total IgG and Total IgM (CSF and Serum); Albumin (CSF and Serum); Borrelia burgdorferi Antibody Index; Albumin Ratio

Preferred Specimen(s)

2 mL serum and 2 mL CSF

Minimum Volume

1 mL serum; 1 mL CSF

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Methodology

Enzyme Linked Immunosorbent Assay (ELISA) • Nephelometry

Performing Laboratory

Focus Diagnostics, Inc
5785 Corporate Avenue
Cypress , CA 90630-4753

Setup Schedule

Set up: Tues, Fri a.m.; Report available: 3-7 days at Focus

Reference Range(s)

Lyme Disease Antibody Index:
≤1.0 Negative
1.1-1.2 Equivocal
≥1.3 Positive
Control Antibody Index:
≤1.0  
Albumin Ratio:  
<0.0078  

Clinical Significance

The Borrelia burgdorferi antibody index is used as an aid for the diagnosis of neuroborreliosis. An increased Borrelia burgdorferi antibody index (> 1.2). Accompanied by a control antibody index of less than 1.0 and an albumin ratio of less than 0.0078 is strong evidence for inrathecal synthesis of organism-specific antibody, and thus CNS involvement by B. burgdorferi. Elevation of either the control antibody index, the albumn ratio, or both may indicate leakage of antibody across the blood-brain barrier which may falsely elevate the B. burgdorferi antibody index.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
85969970LYME DISEASE AB INDEX23833-7Borrelia burgdorferi Ab index
85969980ALBUMIN RATIO1756-6Albumin.CSF/Albumin.SerPl
85969990INTERPRETATION23833-7Borrelia burgdorferi Ab index
85977490CONTROL AB INDEX23833-7Borrelia burgdorferi Ab index

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.