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Test Code


CPT Code(s)



Total Protein, Albumin, Globulin (calculated), Albumin/Globulin Ratio (calculated)

Preferred Specimen(s)

2 mL serum

Transport Container: Serum Separator Tube (SST(R))
Transport Temperature: Room temperature

Minimum Volume

1 mL

Specimen Stability

Room temperature: 7 days
Refrigerated: 30 days
Frozen: 6 months


See individual tests

Setup Days

Set up: Mon-Sat; Report available: 1 day

Reference Range(s)

Protein, Total, Serum
  Male (g/dL) Female (g/dL)
<1 Month 4.1-6.3 4.2-6.2
1-5 Months 4.7-6.7 4.4-6.6
6-11 Months 5.5-7.0 5.6-7.9
1-19 Years 6.3-8.2 6.3-8.2
≥20 Years 6.1-8.1 6.1-8.1
Albumin 3.6-5.1 3.6-5.1
Globulin Male Female
  g/dL (calc) g/dL (calc)
<6 Months 1.3-2.4 1.3-2.1
6-11 Months 1.7-3.0 1.2-2.4
1-19 Years 2.1-3.5 2.0-3.8
≥20 Years 1.9-3.7 1.9-3.7
Albumin/Globulin Ratio 1.0-2.5 (calc)

Clinical Significance

The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis.  Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
974PROTEIN, TOTAL2885-2Protein
981GLOBULIN, CALCULATED10834-0Globulin
982A/G RATIO1759-0Albumin/Globulin

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.