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HYPERCOAGULABILITY PANEL

Test Code

316832X

Includes

PROTEIN C ACTIVITY W/RFX; PROTEIN S ACTIVITY W/RFX; ANTITHROMBIN III ACT W/REFLEX; FACTOR V (LEIDEN) MUTATION; LUPUS ANTICOAGULANT EVAL W/REFLEX; MTHFR DNA MUTATION ; PROTHROMBIN (FACTOR II) MUTATION

Preferred Specimen(s)

(20980) MTHFR DNA MUTATION
WB
5 ML
EDTA (LAVENDER TOP) WHOLE BLOOD, ROOM TEMP
(21470) PROTEIN S ACTIVITY W/RFX
PL
3 ML 3.2% SODIUM CITRATE (LT BLUE-TOP) PLASMA
3.8% SODIUM CITRATE (LT. BLUE-TOP) IS UNACCEPTABLE.
DRAW BLOOD IN LIGHT BLUE-TOP TUBE CONTAINING 3.2% SODIUM
CITRATE, MIX GENTLY BY INVERTING 3-4 TIMES. CENTRIFUGE 15
MINUTES AT 1500g WITHIN 1 HOUR OF COLLECTION. USING A
PLASTIC PIPETTE, REMOVE PLASMA, TAKING CARE TO AVOID THE
WBC/PLATELET BUFFY LAYER AND PLACE INTO A PLASTIC VIAL.
CENTRIFUGE A SECOND TIME AND TRANSFER PLATELET-POOR PLASMA
INTO A NEW PLASTIC VIAL(S). FREEZE IMMEDIATELY AND
TRANSPORT ON DRY ICE.
(21475) PROTEIN C ACTIVITY W/RFX
PL
3 ML
PLASMA (SODIUM CITRATE) FROZEN
*CRITICAL FROZEN*

DRAW BLOOD IN A LIGHT BLUE TOP TUBE CONTAINING 3.2% SODIUM
CITRATE, MIX GENTLY BY INVERTING 3-4 TIMES. CENTRIFUGE 15
MINUTES AT 1500G WITHIN 1 HOUR OF COLLECTION. USING A
PLASTIC PIPETTE, REMOVE PLASMA, TAKING CARE TO AVOID THE
WBC/PLATELET BUFFY LAYER AND PLACE INTO A PLASTIC VIAL.
CENTRIFUGE A SECOND TIME AND TRANSFER PLATELET-POOR PLASMA
INTO A NEW PLASTIC VIAL(S). FREEZE IMMEDIATELY AND
TRANSPORT ON DRY ICE.
(21480) ANTITHROMBIN III ACT W/REFLEX
FP
2 ML
PLASMA (SODIUM CITRATE), FROZEN
STABLE, REFRIGERATED 2 DAYS
(21770) FACTOR V (LEIDEN) MUTATION
WB
5 ML
EDTA WHOLE BLOOD, ROOM TEMPERATURE
STORE AND SHIP AMBIENT IMMEDIATELY, DO NOT FREEZE.
(21775) PROTHROMBIN (FACTOR II) MUTATION
WB
5 ML
EDTA WHOLE BLOOD, ROOM TEMPERATURE
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
FP
3 ML SODIUM CITRATE PLASMA, FROZEN
*CRITICAL FROZEN*

Minimum Volume

(20980) MTHFR DNA MUTATION
1.0 ML
(21470) PROTEIN S ACTIVITY W/RFX
0.5 ML
(21475) PROTEIN C ACTIVITY W/RFX
0.5 ML
(21480) ANTITHROMBIN III ACT W/REFLEX
1.0 ML
(21770) FACTOR V (LEIDEN) MUTATION
3.0 ML
(21775) PROTHROMBIN (FACTOR II) MUTATION
3.0 ML
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
2.0 ML

Alternative Specimen(s)

(21770) FACTOR V (LEIDEN) MUTATION
YELLOW TOP TUBE (ACD)
AMNIOTIC FLUID

Transport Container

(20980) MTHFR DNA MUTATION
LAVENDER TOP
(21470) PROTEIN S ACTIVITY W/RFX
LIGHT BLUE TOP-SODIUM CITRATE
(21475) PROTEIN C ACTIVITY W/RFX
LIGHT BLUE TOP-SODIUM CITRATE
(21480) ANTITHROMBIN III ACT W/REFLEX
LIGHT BLUE TOP-SODIUM CITRATE
(21770) FACTOR V (LEIDEN) MUTATION
LAVENDER TOP
(21775) PROTHROMBIN (FACTOR II) MUTATION
LAVENDER TOP
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
PLASTIC TRANSPORT TUBE

Transport Temperature

(20980) MTHFR DNA MUTATION
ROOM TEMPERATURE
(21470) PROTEIN S ACTIVITY W/RFX
FROZEN
(21475) PROTEIN C ACTIVITY W/RFX
FROZEN
(21480) ANTITHROMBIN III ACT W/REFLEX
FROZEN
(21770) FACTOR V (LEIDEN) MUTATION
ROOM TEMPERATURE
(21775) PROTHROMBIN (FACTOR II) MUTATION
ROOM TEMPERATURE
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
FROZEN

Specimen Stability

(21470) PROTEIN S ACTIVITY W/RFX
ROOM TEMPERATURE: UNACCEPTABLE
REFRIGERATED: UNACCEPTABLE
FROZEN: 14 DAYS
(21475) PROTEIN C ACTIVITY W/RFX
ROOM TEMPERATURE: UNACCEPTABLE
REFRIGERATED: UNACCEPTABLE
FROZEN: 14 DAYS
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
ROOM TEMPERATURE: UNACCEPTABLE
REFRIGERATED: UNACCEPTABLE
FROZEN: 90 DAYS

Methodology

(20980) MTHFR DNA MUTATION
HYBEACONS
(21470) PROTEIN S ACTIVITY W/RFX
CLOT DETECTION, MICROLATEX PARTICLE-MEDIATED IMMUNOASSAY
(21475) PROTEIN C ACTIVITY W/RFX
CHROMOGENIC ASSAY
(21480) ANTITHROMBIN III ACT W/REFLEX
CHROMOGENIC SUBSTRATE, FIXED RATE TIME NEPHELOMETRY
(21770) FACTOR V (LEIDEN) MUTATION
PCR AND LUMINESENT DETECTION
(21775) PROTHROMBIN (FACTOR II) MUTATION
HYBEACONS
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
PHOTO OPTICAL CLOT DETECTION

Performing Laboratory

Nichols Institute
33608 Ortega Hwy.
San Juan Cap, CA 92690

Setup Days

(20980) MTHFR DNA MUTATION
SUN, WED, FRI
(21470) PROTEIN S ACTIVITY W/RFX
MON - FRI
(21475) PROTEIN C ACTIVITY W/RFX
MON - SAT
(21480) ANTITHROMBIN III ACT W/REFLEX
TUES - SAT
(21770) FACTOR V (LEIDEN) MUTATION
MON - SUN
(21775) PROTHROMBIN (FACTOR II) MUTATION
MON, WED, SAT
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
MON - SAT

Report Available

(20980) MTHFR DNA MUTATION
6 - 8 DAYS
(21470) PROTEIN S ACTIVITY W/RFX
2 - 4 DAYS
(21475) PROTEIN C ACTIVITY W/RFX
3 - 4 DAYS
(21480) ANTITHROMBIN III ACT W/REFLEX
3 - 5 DAYS
(21770) FACTOR V (LEIDEN) MUTATION
6 - 8 DAYS
(21775) PROTHROMBIN (FACTOR II) MUTATION
8 - 10 DAYS
(21900) LUPUS ANTICOAGULANT EVAL W/REFLEX
3 - 5 DAYS

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.