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Celiac Disease Comprehensive Panel

Test Code


CPT Code(s)

82784, 83516


Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

If the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Preferred Specimen(s)

5 mL serum

Minimum Volume

1 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic


Immunoassay (IA) • Immunoturbidimetric

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

Reference Range(s)

(tTG) Antibody, (IgA)

<4 U/mL No antibody detected
≥4 U/mL Antibody detected

IgA, Serum
Cord Blood 1-3 mg/dL
1 Month 2-43 mg/dL
2-5 Months 3-66 mg/dL
6-9 Months 7-66 mg/dL
10-12 Months 12-75 mg/dL
1-3 Years 24-121 mg/dL
4-6 Years 33-235 mg/dL
7-9 Years 41-368 mg/dL
10-11 Years 64-246 mg/dL
12-13 Years 70-432 mg/dL
14-15 Years 57-300 mg/dL
≥16 Years 81-463 mg/dL

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
40000700TISSUE TRANSGLUTAMINASE AB, IGA31017-7Tissue transglutaminase Ab.IgA
86010040INTERPRETATIONPending assignment

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.