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Antiphospholipid Syndrome Diagnostic Panel [19872X]

Test Code


CPT Code(s)

85613, 85730, 86146 (x3), 86147 (x3)


Cardiolipin IgG, IgM, IgA; B2-Glycoprotein I IgG, IgM, IgA; Lupus Anticoagulant Evaluation with Reflex

Lupus Anticoagulant Evaluation with Reflex:
If PTT-LA is >40 seconds, then Hexagonal Phase Confirmation will be performed at an additional charge (CPT code(s): 85598).
If dRVVT is >45 seconds, then dRVVT Confirmation will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirmation is positive, then dRVVT 1:1 dilution will be performed at an additional charge (CPT code(s): 85613).

Preferred Specimen(s)

3 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

2 mL

Collection Instructions

Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial.

Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.

Specimen Container

Plastic screw-cap vial

Transport Temperature


Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria

Hemolysis • Grossly lipemic • Serum


Immunoassay (IA) • Photo-Optical Clot Detection

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Varies; Report Available: 4 days

Reference Range(s)

See individual tests

Clinical Significance

This assay may be useful in supporting or ruling out a diagnosis of antiphospholipid syndrome.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
4662Cardiolipin Ab (IgG)3181-5Cardiolipin Ab.IgG
4661Cardiolipin Ab (IgA)5076-5Cardiolipin Ab.IgA
4663Cardiolipin Ab (IgM)3182-3Cardiolipin Ab.IgM
14357APTT-LA Screen34571-0Coagulation surface induced.lupus sensitive
143583Hexagonal Phase Confirm.33930-9Coagulation surface induced.hexagonal phase phospholipid
143593dRVVT Confirmation52756-4Coagulation dilute Russell viper venom induced.excess phospholipid
145653ALupus Anticoagulant Eval.3281-3Lupus anticoagulant
33693CdRVVT 1:1 Mix75513-2DRVVT with 1:1 Pooled Normal Plasma
3369AdRVVT Screen6303-2Coagulation dilute Russell viper venom induced
3369CdRVVT6303-2Coagulation dilute Russell viper venom induced
3369IdRVVT Mix Interpretation:50008-2Mixing studies
883Thrombin Clotting Time3243-3Coagulation thrombin induced
36552Beta2-Glycoprotein I (IgA)21108-6Beta 2 glycoprotein 1 Ab.IgA
36553Beta2-Glycoprotein I (IgM)16136-4Beta 2 glycoprotein 1 Ab.IgM
36554Beta2-Glycoprotein I (IgG)16135-6Beta 2 glycoprotein 1 Ab.IgG

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.