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Test Code


CPT Code(s)



If HPV DNA, High Risk is Detected, HPV Genotypes 16 and 18, will be performed at an additional charge (CPT code(s): 87625).

Preferred Specimen(s)

Specimen Type Refer to Special Handling Instructions
Specimen State Room temperature
Since the HPV Genotype assay is validated for liquid
cytology specimens only, no other sample types are
acceptable for this test. Both Cytyc ThinPrep(R) and TriPath
SurePath(R) samples are acceptable.

ThinPrep(R): 8 mL (6 mL minimum) residual PreservCYT(R))
fluid collected in a Liquid Cytology (PreservCYT(R))
Preservative (ThinPrep(R)) vial

SurePath(TM): Cell rich pellet in 2 mL SurePath(TM) fluid
plus 2 mL residual SurePath(TM) fluid collected in
SurePath(TM) vials, post processing of the pap smear.

Collect the sample as usual, according to the manufacturer's
Residual (PreservCYT(R)) fluid for ThinPrep(R) samples or
Cell rich pellet in 2 mL SurePath(TM) fluid plus 2 mL
residual SurePath(TM) fluid for SurePath(TM) samples.

Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable

SurePath(TM) (residual fluid):
Room temperature: 30 days
Refrigerated: 30 days
Frozen: Unacceptable

SurePath(TM) (cell pellet):
Room temperature: 14 days
Refrigerated: 14 days
Frozen: Unacceptable

Transport Container

Refer to handling instructions


Digene Hybrid Capture II™

Performing Laboratory


Setup Days


Report Available


Reference Range(s)

HPV DNA, High Risk Not detected
  HPV16 DNA, Invader® Not detected
  HPV18 DNA, Invader® Not detected

Clinical Significance

HPV is the causative agent of cervical dysplasia and cervical carcinoma. The Hybrid Capture assay detects high-risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. The reflex test only identifies whether the high risk types detected are genotypes 16 or 18.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
Z3261HPV DNA,HIGH RISK30167-1Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+68 DNA

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.