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Interferon-Beta IgG, MAID (Reflex/neutralization) [19509X]
Test Code
19509
CPT Code(s)
83520
Includes
If the Interferon-beta IgG ELISA is positive, Interferon-beta (IFNb) Antibody Neutralization Assay will be performed at an additional charge (CPT code(s): 86382, 87253).
Preferred Specimen(s)
1.5 mL serum
Minimum Volume
0.5 mL
Collection Instructions
Collect sample at least 8 hours after interferon injection. Verify medication: (Avonex, Rebif, Betaseron)
If the patient has been on therapy, please provide the medication and duration.
Note: If patient is not on therapy, Focus needs to know why the ordering physician needs the test to be run. Testing of specimens without this information will be delayed until information is provided.
Specimen Container
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Methodology
Multi-Analyte Immunodetection (MAID)
Performing Laboratory
Focus Diagnostics, Inc.
5785 Corporate Ave, Suite 200
Cypress, CA 90630
Setup Schedule
Monday Morning; Report available: 3 Days
Reference Range(s)
<4.0 Units
Clinical Significance
Some multiple sclerosis patients receiving recombinant
interferon-beta (IFNb) develop IFNb-specific antibodies
that may block the therapeutic effect of the treatment.
This assay screens for IgG antibodies capable of binding
to IFNb; all samples with detectable IFNb binding
antibodies are then tested for IFNb neutralizing
antibodies, using a bioassay. Approximately two weeks
are required to perform the neutralization bioassay;
those results will be reported separately when available.
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
(The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.)
* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.