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Heroin Metabolites, Quantitative, Urine

Test Code

18969

CPT Code(s)

83925

Includes

Codeine, Morphine, 6-Acetylmorphine

Preferred Specimen(s)

10 mL random urine

Minimum Volume

5 mL

Collection Instructions

Collect in a plastic urine container. Do not use any preservatives or additives.

Transport Container

Plastic urine container

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Performing Laboratory

Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386

Setup Schedule

Set up: Wed, Sat a.m.

Reference Range(s)

Limit of quatitation

Codeine 100 ng/mL
Morphine 100 ng/mL
6-Acetylmorphine  5 ng/mL

Clinical Significance

Confirmation of screen positive results, 6-Acetylmorphine (6-AM) is a metabolite of heroin. Heroin itself is not active, but it is rapidly converted (t1/2 <6 minutes) to 6-acetylmorphine and further to morphine (t1/2 <40 minutes). Both 6-AM and morphine have euphoric effects. 6-AM is rapidly eliminated and excreted into the urine and the 'detection window' is <24 hours. Therefore, 6-AM negative urine does not exclude heroin abuse, but its presence confirms it.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
86007276CODEINE URINE3508-9Codeine
86007277MORPHINE URINE3831-5Morphine
860072786 ACETYLMORPHINE URINE10975-16-Monoacetylmorphine

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.