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Heroin Metabolites, Quantitative, Urine

Test Code


CPT Code(s)

80361, 80356 (HCPCS: G0480)


Codeine, Morphine, 6-Acetylmorphine

Preferred Specimen(s)

10 mL random urine - no preservative

Minimum Volume

5 mL

Collection Instructions

Collect in a plastic urine container. Do not use any preservatives or additives.

Transport Container

Plastic urine container

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 30 days


Chromatography/Mass Spectrometry

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Performing Laboratory

Quest Diagnostics Nichols Institute
27027 Tourney Road
Valencia, CA 91355-5386

Setup Schedule

Set up: Wed, Sat a.m.

Clinical Significance

Confirmation of screen positive results, 6-Acetylmorphine (6-AM) is a metabolite of heroin. Heroin itself is not active, but it is rapidly converted (t1/2 <6 minutes) to 6-acetylmorphine and further to morphine (t1/2 <40 minutes). Both 6-AM and morphine have euphoric effects. 6-AM is rapidly eliminated and excreted into the urine and the 'detection window' is <24 hours. Therefore, 6-AM negative urine does not exclude heroin abuse, but its presence confirms it.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
86006927CODEINE, URINE3508-9Codeine
86006928MORPHINE, URINE3831-5Morphine
860069296 ACETYLMORPHINE, URINE10975-16-Monoacetylmorphine

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.