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Cortisol, LC/MS/MS, Saliva, 4 Samples

Test Code


CPT Code(s)

82530 (x4)

Patient Preparation

1. Saliva should be collected at the time(s) prescribed by your doctor.
2. No food or fluids for 30 minutes prior to collection.
3. Do not use any creams, lotions, or steroid inhalers immediately prior to collection.
4. Avoid any activity that can cause your gums to bleed, including brushing and flossing your teeth. Consult with your doctor if this is a chronic problem.
5. Do not use this kit on children under 3 years of age or any patient with increased risk of swallowing or choking.

Preferred Specimen(s)

0.5 mL (x4) saliva

Minimum Volume

0.2 mL (x4)

Collection Instructions

1. Rinse mouth thoroughly with water and discard. Do not swallow.
2. Hold the Salivette® at the rim of the suspended insert and remove the stopper.
3. Remove the swab.
4. Place the swab under the tongue until well saturated, approximately 1 minute.
5. Return the saturated swab to the suspended insert and close the Salivette® firmly with the stopper.
6. Do not remove the tube holding the insert. The Salivette® should be sent to the lab with the swab inside.
7. Label the Salivette® with the patient name, date and time of collection, and any other identifying information.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 5 days
Refrigerated: 7 days
Frozen: 2 years

Reject Criteria

Any tubes under than Salivette® • Hemolysis


Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Performing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

Setup Schedule

Set up: Sun-Thurs; Report Available: 6-9 days

Reference Range(s)

See Laboratory Report

Clinical Significance

Measurements of salivary cortisol can be useful in the screening of patients for Cushing's syndrome and other adrenal disorders. Specific reference ranges have been defined based upon the time of day that specimen is collected. These reference intervals have been defined using specimens obtained from individuals adhering to a normal sleep/wake cycle.

Alternative Name(s)

Cortisol, Saliva, LC/MS/MS, Hydroxycortisone, Compound F

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
86006703Cortisol, Saliva Sample 157687-6Cortisol^1st specimen
86008975Draw Date 133882-2Collection date
86008976Draw Time 149049-0Collection time
86006704Cortisol, Saliva Sample 257685-0Cortisol^2nd specimen
86009038Draw Date 233882-2Collection date
86009039Draw Time 249049-0Collection time
86006705Cortisol, Saliva Sample 357688-4Cortisol^3rd specimen
86009040Draw Date 333882-2Collection date
86009041Draw Time 349049-0Collection time
86006706Cortisol, Saliva Sample 457689-2Cortisol^4th specimen
86009042Draw Date 433882-2Collection date
86009043Draw Time 449049-0Collection time

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.