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Prometheus® Celiac PLUS

Test Code


CPT Code(s)

81382 (x2), 82784, 83520 (x3), 86255

Preferred Specimen(s)

2 mL serum collected in a red-top tube (no gel)
Minimum: 5 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume

Serum: 0.5 mL

Collection Instructions

Both Celiac Genetics (HLA DQ2/DQ8) and Celiac Serology will be performed. Both serum and whole blood specimens are required for this test.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Whole blood
Room temperature: Not established
Refrigerated: 8 days
Frozen: Unacceptable



Performing Laboratory

Therapeutics and Diagnostics
9410 Carroll Park Drive
San Diego, CA 92121 

Setup Schedule

Set up: Mon-Fri a.m.; Report available: 11 days

Reference Range(s)

See Laboratory Report

Clinical Significance

Most celiac patients carry either the DQ2 (about 9 5% of celiacs) or the DQ8 haplotype (about 5% of celiacs). There are two DQ2 haplotypes, but only one DQ8 haplotype-specific combination that may confer different risks for the development of celiac disease, as shown above(3).
1) Pietzak M, et al., Stratifying Risk for Celiac Disease in a Large At-Risk United States Population by Using HLA Alleles. Clin Gastroenterol Hepatol. 2009; 7:966 - 971.
2) Fasano A, Berti I, et al., Prevalence of celiac disease in at-risk and not at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003; 163: 286-292.
3) Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM, Pathomechanisms in celiac disease. Best Pract Res Clin Gastroenterol. 2005; 19: 373-387.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
ASTMRCVDResults Received19146-0Reference lab test results

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.