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HLA Typing for Celiac Disease

Test Code


CPT Code(s)

81376, 81382


HLA-DQ2 (DQA1*05/DQB1*02), HLA-DQ8 (DQA1*03/DQB1*0302), HLA-DQA1*, HLA-DQB1*

Preferred Specimen(s)

5 mL whole blood collected in an EDTA lavender-top tube.

Minimum Volume

3 mL

Alternative Specimen(s)

Whole blood collected in: ACD (yellow-top) tube or sodium heparin (green-top) tube

Collection Instructions

A separate ACD (yellow-top) or EDTA (lavender-top) tube must be submitted for all HLA testing. If submitted with any other test requiring an ACD or EDTA tube, please submit a separate tube for this test. Do not open tube.

Transport Container

EDTA (lavender-top) tube

Transport Temperature

Room temperature
Shipping refrigerated is acceptable

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: Unacceptable

Reject Criteria

Received frozen


Polymerase Chain Reaction Amplification followed by Sequence Specific Oligonucleotide Probes (PCR-SSO)

Performing Laboratory

Quest Diagnostics Nichols Chantilly
14225 Newbrook Drive P.O. Box 10841
Chantilly, VA 20153

Setup Days


Report Available

7 days

Reference Range(s)

See Laboratory Report

Clinical Significance

Celiac disease is a multigenic immune-mediated enteropathy triggered by dietary proteins, commonly known as glutens, present in wheat, barley, and rye. Varied clinical manifestations begin either in childhood or adult life. Its prevalence in the united states ranges from 0.5 to 1%. Celiac disease is strongly associated with the HLA genetic region. Approximately 90% of celiac patients express the HLA-DQ2 molecule. Most of the DQ2 negative patients express the HLA-DQ8 molecule. Gluten peptides presented by these HLA molecules induce an abnormal mucosal immune response and tissue damage.  The HLA-DQ molecules are heterodimers of an alpha and a beta chain. The beta chain of HLA-DQ2 is coded by HLA-DQB1*02 and of DQ8 by HLA-DQB1*0302. HLA-DQB1 genotyping allows clinicians to evaluate the genetic predisposition for celiac disease in a patient.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
86000618RESULTS REVIEWED BY:Pending assignment

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.