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ColoVantage® (Methylated Septin 9)

Test Code


CPT Code(s)

**This test is for non-New York State patient testing only. For New York State patient testing, use 16984, ColoVantage® (Methylated Septin 9) (NY).**

Preferred Specimen(s)

10 mL frozen plasma collected in an EDTA (lavender-top) tube

Minimum Volume

5 mL

Collection Instructions

This test requires 10 mL of plasma (samples with less than 5 mL plasma will be rejected). To obtain this volume of plasma, collect blood in (x2) 10 mL EDTA (lavender-top) tubes or (x5) standard EDTA (lavender-top) tubes. Centrifuge the blood samples, separate plasma and combine them. Send plasma in a single 10 mL pour-off tube. If a 10 mL pour-off tube is not available, (x2) 5 mL pour-off tubes can be used.

Specimen Container

Plastic screw-cap vial

Transport Temperature


Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 28 days


Real-Time Polymerase Chain Reaction (RT-PCR)

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Daily a.m.; Report available: 3 days

Reference Range(s)

Not detected

Clinical Significance

Methylated Septin 9 is a DNA marker associated with colorectal cancer.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
86004306RESULT65810-4SEPT9 gene methylation
86004307INTERPRETATIONPending assignment

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.