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Inflammatory Bowel Disease Differentiation Panel

Test Code


CPT Code(s)

86021 (x3), 86671 (x2)


ANCA Screen with Reflex to ANCA Titer, Myeloperoxidase Ab (MPO), Proteinase-3 Antibody, Saccharomyces cerevisiae Ab (ASCA) IgG, Saccharomyces cerevisiae Ab (ASCA) IgA
If ANCA Screen is positive, C-ANCA Titer and/or  P-ANCA Titer  and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86021 for each titer performed) .

Preferred Specimen(s)

2 mL serum

Minimum Volume

1.4 mL

Specimen Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria

Gross hemolysis • Lipemic specimens


Immunoassay (IA)

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Tues-Sat p.m.; Report available: 2 days

Reference Range(s)

ANCA Screen Negative
P-ANCA Titer <1:20
C-ANCA Titer <1:20
Atypical P-ANCA Titer <1:20
Myeloperoxidase Antibody
<1.0 AI No antibody detected
≥1.0 AI Antibody detected
Proteinase-3 Antibody
<1.0 AI No antibody detected
≥1.0 AI Antibody detected
Saccharomyces cerevisiae (IgG)
≤20 U Negative
20.1-29.9 U Equivocal
≥30 U Positive
Saccharomyces cerevisiae (IgA)
≤20 U Negative
20.1-24.9 U Equivocal
≥25 U Positive

Clinical Significance

These tests are intended to aid in the diagnosis of Crohn's Disease. A positive P-ANCA aids in the differentiation of patients with ulcerative colitis.

Alternative Name(s)

IBD Panel

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
2695AProteinase-3 Ab46267-1Proteinase 3 Ab
3277AMyeloperoxidase Ab46266-3Myeloperoxidase Ab
70171AANCA Screen17351-8Neutrophil cytoplasmic Ab
13870AS cerevisiae Ab (IgA)47320-7Saccharomyces cerevisiae Ab.IgA
13871AS cerevisiae Ab (IgG)47321-5Saccharomyces cerevisiae Ab.IgG

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.