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IGF-I, LC/MS

Test Code

16293

CPT Code(s)

84305

Preferred Specimen(s)

0.5 mL serum

Minimum Volume

0.3 mL

Collection Instructions

For red-top tubes, allow blood to clot 10-15 minutes at room temperature. Separate serum from cells and refrigerate. If sample collected in glass collection tube, transfer to plastic container.

Specimen Container

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 48 hours
Refrigerated: 5 days
Frozen -20° C: 28 days
Frozen -70° C: 21 days

Reject Criteria

Gross hemolysis • Gross lipemia • Received in glass tube • Grossly icteric • Plasma

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

This test was developed and its performance characteristics were determined by Quest Diagnostics Nichols Institute. Performance characteristics refer to the analytical performance of the test.

Performing Laboratory

Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

Setup Schedule

Set up: Mon-Fri, Sun p.m.; Report available: 5 days

Reference Range(s)

See Laboratory Report

Clinical Significance

Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations.
Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.

Alternative Name(s)

Somatomedin-C, Insulin-Like Growth Factor, IGF-1

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
16293IGF-I, LC/MS2484-4Insulin-like growth factor-I
ASTMRCVDResults Received19146-0Reference lab test results

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.