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Helicobacter pylori Urea Breath Test (UBiT®)

Test Code


CPT Code(s)


Patient Preparation

Patient should fast one hour before collection of baseline breath sample. Patient must be off antibiotics, proton-pump inhibitors (i.e., Prilosec™, Nexium™, Protonix™, Aciphex™) and bismuth preparations two weeks prior to administration of test.
Pranactin®-citric contains a small amount of aspartame sweetener. Test may not be suitable for patients with phenylketonuria whose dietary phenylalanine should be restricted.

Preferred Specimen(s)

Breath in Capped pink and blue breath Ubit® UBT collection bag

Collection Instructions

The test can only be performed on specimens from patients greater than 18 years old.
Human breath: Paired breath samples (pre and post) collected in Meretek kit bags and must be submitted together. Follow instructions provided with kit.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: Unacceptable
Frozen: Unacceptable

Reject Criteria

Specimen types other than BreathTek™ UBiT® bags • Specimens from patients <18 years old


Infra-red Spectrophotometry (IR)

Performing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

Setup Schedule

Set up: Mon-Fri; Report available: 2-5 days

Reference Range(s)

Not detected

Clinical Significance

Helicobacter pylori is a gram-negative microaerophilic curved bacillus with an affinity for human gastric mucosa. H. pylori has been identified as an important pathogen in the upper GI tract. The casual relationship between H. pylori and chronic active gastritis, duodenal ulcers, and gastric ulcers has been well documented. BreathTek™ UBiT® for H. pylori is a non-invasive, non-radioactive method for detecting urease activity associated with H. pylori infection. It is FDA approved to confirm cure and offers 95.2% sensitivity and 89.7% specificity compared with endoscopic methods.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
3887H.pylori UBiT(R)29891-9Carbon dioxide^post dose urea

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.