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Thrombosis Panel

Test Code

11051

CPT Code(s)

85300,85303,85306,85307

Includes

Protein C Activity, Protein S Activity, Antithrombin III Activity, Activated Protein C-Resistance

Preferred Specimen(s)

5 mL frozen plasma collected in a 3.2% sodium citrate (light-blue top) tube

Minimum Volume

2.5 mL

Collection Instructions

Platelet-poor plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcl). Freeze immediately and ship on dry ice.

Transport Container

Plastic screw-cap vial

Transport Temperature

Frozen

Reject Criteria

Received room temperature • Received refrigerated • Hemolyzed

Methodology

aPTT-Based Assay (Clot-Based) • Clot Detection • Photometry/Optical • Spectrophotometry (SP)

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

Limitations

Protein C, Activity: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: decrease; Heparin (UFH or LMWH): UFH-no effect, LMWH-may falsely increase at higher levels; Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): may falsely increase.
Protein S, Activity: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: decrease; Heparin (UFH or LMWH): may falsely increase at values approximately greater than 1.0 IU/mL; Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Antithrombin III Activity: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect to decrease (UFH may decrease levels physiologically but no assay interference); Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Activated Protein C Resistance: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect; Dabigatran or Argatroban (Thrombin Inhibitors): unable to obtain assay endpoint; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.

Reference Range(s)

See individual tests

Clinical Significance

This panel is useful to determine the etiology of various hypercoagulability states.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result
Code
Result NameLOINC CodeComponent Name
86011545ACTIVATED PROTEIN C RESISTANCE13590-5Activated protein C resistance
30021100PROTEIN C, ACTIVITY27819-2Protein C actual/Normal
30021400PROTEIN S, ACTIVITY27822-6Protein S actual/Normal
31000100ANTITHROMBIN III ACTIVITY27811-9Antithrombin actual/Normal

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.