Amniocentesis

What To Think About

• Normal results from amniocentesis do not guarantee that your fetus will be healthy.
• Amniocentesis is not done as a general screening test for birth defects because it has some risk to your fetus and cannot find some common birth defects. There is a chance (about 1 in 400) that this test may cause a miscarriage.¹ In some studies, the risk is a little higher, about 2 to 4 in 400.² Amniocentesis can be done to help you prepare if your fetus has a possible birth defect or to help you make a decision about ending the pregnancy if a serious problem is found. For more information about amniocentesis in early pregnancy, see:

  Should I have an amniocentesis?

• In rare cases, amniocentesis is done between the 12th and 15th weeks of pregnancy because there may be a greater risk to your fetus. Talk to your doctor about the risks and benefits of an early amniocentesis.
• Amniocentesis cannot be done easily if the amount of amniotic fluid is very small or if the placenta is in front of your fetus.
• Chorionic villus sampling (CVS) is another test that can find many fetal problems. CVS can be done earlier in pregnancy (at about 10 to 12 weeks) than amniocentesis, and results are ready sooner. It can find more than 100 genetic diseases. One study showed that CVS also has about a 1-in-400 chance of miscarriage when it is done by a highly trained provider.¹ CVS cannot be used to find neural tube defects. For more information, see the medical test Chorionic Villus Sampling (CVS).
• Fetoscopy is a new test that allows your doctor to look at your fetus using a long, thin tube put through a small cut in your belly. Samples of your fetus's blood and tissue also can be collected. Fetoscopy carries a higher chance of miscarriage than amniocentesis and is not widely available. For more information, see the medical test Fetoscopy.
• Amniocentesis has a very small chance of causing bleeding that could lead to mixing your blood and your fetus's. So if you have Rh-negative blood, you will be given a vaccine (RhoGAM) to prevent Rh sensitization which could harm your fetus if he or she has Rh-positive blood.
• Amniotic fluid has cells that have been shed by your developing fetus. The cells are checked for the number and size of chromosomes (karyotype) to see if there are any problems. For more information, see the medical test Karyotype Test.
• If you have abnormal results from amniocentesis, you should ask your doctor or a genetic counselor for help in making decisions about the problems your fetus may have and about continuing the pregnancy. It will also be helpful to understand your possible risks with future pregnancies.

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Author:	Sandy Jocoy, RN	Last Updated: May 14, 2008
Medical Review:	Sarah Marshall, MD - Family Medicine Siobhan M. Dolan, MD, MPH - Reproductive Genetics
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