Borderline Personality Disorder

Cause

The cause of borderline personality disorder is not well-understood. It may be a result of an imbalance of chemicals in the brain called neurotransmitters, which help regulate mood. Mood is also influenced by genetic and environmental influences.

Borderline personality disorder is 5 times more common among people whose parents or siblings have the disorder.⁴ It is also seen more often in families who have other mental health conditions such as antisocial personality disorder, substance abuse problems, and mood disorders like depression.³

People who develop this disorder often have experienced significant childhood trauma, such as sexual, physical, or emotional abuse; neglect; or early loss of or separation from a parent. When this trauma is combined with certain personality traits, such as reacting poorly to stress or having problems with anxiety, the risk for developing borderline personality disorder increases.

Although experts know that people with borderline personality disorder have impaired function in parts of the brain, it is still not clear whether the problems are caused by—or are a consequence of—the disorder.⁵

Go to previous section	Go to top of page	Go to next section
Author:	Jeannette Curtis	Last Updated: March 26, 2007
Medical Review:	Kathleen Romito, MD - Family Medicine Lisa S. Weinstock, MD - Psychiatry
© 1995-2008 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.