Initial studies have shown a topical cream of zinc oxide/glycine used
to treat facial
cold sores may be helpful.1
People in one small study who used the cream as soon as possible after a cold
sore outbreak had a shorter duration of cold sore blisters—most blisters healed
within 5 days instead of 6½ days.2
Some people using this cream experienced a few side effects, such as
severe skin irritation and dryness.
Most cold sores heal on their own without prescription medications or
complementary therapies.