Atypical squamous cells (ASC) of the cervix

Atypical squamous cells (ASC) are abnormal cells found on a Pap test, but the reason for the abnormalities is not known. The causes of ASC include infection or inflammation.

ASC is further classified as:

  • ASC of undetermined significance (ASC-US).
  • ASC but cannot exclude high-grade squamous intraepithelial lesion (HSIL) (ASC-H).

If you have ASC-US abnormalities, your health professional will probably recommend watchful waiting or human papillomavirus (HPV) testing. ASC-H abnormalities have a higher risk of being identified as more severe changes and are evaluated with colposcopy.



Author: Shannon Erstad, MBA/MPHLast Updated: January 12, 2007
Medical Review: Joy Melnikow, MD, MPH - Family Medicine
Barbara S. Apgar, MD, MS - Family Medicine, Women's Health
Ross Berkowitz, MD - Obstetrics and Gynecology

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