Risk of allergic reaction to rabies vaccine (HDCV)

As many as 6% of people receiving booster doses of rabies vaccine (HDCV) as part of a pre- or postexposure vaccination regimen experience an allergic reaction. The reaction is rare in people receiving first-time (primary) immunization.1 Symptoms include:

  • Hives (urticaria).
  • Pain and inflammation of joints.
  • Swelling.
  • Nausea and vomiting.
  • Fever.

These symptoms are never life-threatening. If symptoms are serious, other vaccines such as RVA or PCEC can be given instead of HDCV on the same schedule.



Author: Amy Fackler, MA
Debby Golonka, MPH
Last Updated: September 19, 2006
Medical Review: Adam Husney, MD - Family Medicine
Christine Hahn, MD - Epidemiology

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