Oral diabetes medications that can cause low blood sugar

The following sulfonylurea medications for diabetes can cause low blood sugar as a side effect.

  • Glipizide (Glucotrol)
  • Glyburide (such as DiaBeta, Glynase, Micronase)
  • Glimepiride (Amaryl)

Repaglinide (Prandin) and nateglinide (Starlix) are not sulfonylurea medications. However, they work in the same way and can also cause low blood sugar as a side effect.

You are unlikely to develop low blood sugar levels if you are taking:

  • Metformin (Glucophage).
  • Rosiglitazone (Avandia).
  • Pioglitazone (Actos).


Author: Caroline Rea, RN, BS, MSLast Updated: July 11, 2006
Medical Review: Caroline S. Rhoads, MD - Internal Medicine
Matthew I. Kim, MD - Endocrinology & Metabolism

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