QNatal® Advanced Q&A

Want to know more? Get the QNatal® Advanced basics or call 1.866.GENE.INFO (1.866.436.3463).

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  • What conditions can QNatal® Advanced detect?

    QNatal® Advanced can detect:

    • Trisomy 21 (Down syndrome)
    • Trisomy 18 (Edwards syndrome)
    • Trisomy 13 (Patau syndrome)
    • Monosomy X (Turner syndrome)
    • Klinefelter syndrome (XXY)
    • Triple X and XYY syndromes

  • Which patients can have this test?

    Your high-risk obstetric patients who

    • Are 35 years old or older
    • Have had an abnormal ultrasound
    • Have had a previous pregnancy with one of these conditions
    • Have a positive maternal serum screening test

    You can order this test for women who are carrying more than one fetus (e.g., twins or triplets). The test cannot tell which fetus is affected. Women who used another woman’s egg (i.e., IVF donor egg) to get pregnant can also be tested.

    This test is not for women who

    • Have received a bone marrow transplant

  • How early can the test be given?

    As early as 10 weeks gestation.

  • How is the test performed?

    The test is performed on a blood sample. Two tubes of the patient's blood are collected and sent to the lab for testing. Fetal and maternal DNA are then amplified, measured, and analyzed for both common and rare fetal chromosomal abnormalities. These data are further analyzed using state-of-the-art bioinformatics that calculate the genetic status of the fetus and a risk assessment is made.

  • How accurate is the test?

    DNA sequencing technology enables consistently high levels of detection across all chromosomes evaluated. QNatal® Advanced pinpoints fetal aneuploidies with excellent detection accuracy across all common and rare fetal chromosomal abnormalities. It uses advanced sequencing technology to identify chromosome numbers. This test can also determine sex.

  • What does ACOG recommend with regard to noninvasive
    prenatal testing?

    The American Congress of Obstetricians and Gynecologists (ACOG) recommends the use of noninvasive prenatal tests in women at increased risk of aneuploidy or as a follow-up test for women with a positive first- or second-trimester maternal serum screening result.1

    1. The American College of Obstetricians and Gynecologists Committee on Genetics and the
        Society for Maternal-Fetal Medicine Publications Committee. Noninvasive prenatal testing
        for fetal aneuploidy. Committee Opinion No. 545. Obstet Gynecol. 2012;120(6):1532-1534.

  • How do I order QNatal® Advanced?

    The test code is:

    The CPT Code* is:

    Specimen requirements:

    • 20 mL (minimum 16 mL) whole blood collected in two Streck tubes (glass tubes with black and tan stopper)
    • Store specimens at room temperature; do not refrigerate or freeze

    For more information, contact your sales representative, email a genetic counselor at GENEINFO@QuestDiagnostics.com, or call 1.866.GENE.INFO (1.866.436.3463).

    *   The CPT codes provided are based on AMA guidelines and are for informational purposes only. 
         CPT coding is the sole responsibility of the billing party. Please direct any questions regarding
         coding to the payer being billed.
    ** Not currently available in NY.