HLA Test Menu
Click on test name for additional test-specific information.
| ||
|---|---|---|
| Test Code | Test Name | Clinical Applications |
| [15584Z]–15584 | HLA-B27 DNA Typing | Confirm the diagnosis of ankylosing spondylitis, related spondyloarthropathies, and acute anterior uveitis. |
| [17135X]–17135 | HLA Typing for Celiac Disease HLA-DQ2 (DQA1*05/DQB1*02) and -DQ8 | Assess risk of Celiac Disease in symptomatic patients and in family members of patients with Celiac Disease. More than 97% of Celiac patients carry either HLA-DQ2. (DQA1*05/DQB1*02) or HLA-DQ8 (DQA1*03/DQB1*0302) or both. However, 39% of the general U.S. population carry these HLA-DQ variants, as a consequence, the presence of HLA-DQ2 or DQ8 or both variants is not per se diagnostic of Celiac Disease. |
| [34399Z]–34399 | HLA Typing for Narcolepsy (HLA-DR15 and DQB1*0602) | Differentiate between narcolepsy and other sleep disorders |
| 16773 | HLA-A29 DNA Typing | Birdshot retinochoroidopathy (BSCR) is a rare posterior uveitis, characterized by distinctive, multiple, hypopigmented choroidal and retinal lesions. At least 96% of patients, if not all, share the major histocompatibility antigen, HLA-A29. However, most HLA-A29 positive individuals do not have this disease. Together with clinical manifestations, HLA-A29 typing is used for diagnosis of BSCR. |
| 16775 | Behcet's disease (BD) is a chronic inflammatory disease, characterized by oral aphthous ulcers, genital ulcers, and skin lesions. Between 50-80% of BD patients are HLA-B51 positive. | |
| [10951X]–10951 | HLA-A Class I DNA Typing | Determine susceptibility to certain diseases, especially HLA-associated autoimmune disease. |
| [10950X]–10950 | HLA-B Class I DNA Typing | |
| [15463X]–15463 | HLA-C Class I DNA Typing | |
| [10953X]–10953 | HLA-DQB1 Class II DNA Typing | |
| [10952X]–10952 | HLA-DRB1 Class II DNA Typing | |
| ||
| Test Code | Test Name | Clinical Application |
| [19774X]–19774 | HLA-B*5701 Typing | HLA-B*5701 has been shown in retrospective clinical studies to be associated with Abacavir hypersensitivity reaction (HSR) in HIV patients. In Abacavir-naive patients, HLA-B*5701 genotyping may be useful for risk stratification. |
| [40045X]–40045 | HLA-B*1502 Typing | Dangerous or even fatal skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with the HLA-B*1502 allele. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians. HLA-B*1502 genotyping may be useful for risk stratification. |