HLA Test Menu

Click on test name for additional test-specific information.

Disease Associations

Test Code Test Name Clinical Applications
[15584Z]–15584 HLA-B27 DNA Typing Confirm the diagnosis of ankylosing spondylitis, related spondyloarthropathies, and acute anterior uveitis.
[17135X]–17135 HLA Typing for Celiac Disease HLA-DQ2 (DQA1*05/DQB1*02) and -DQ8 Assess risk of Celiac Disease in symptomatic patients and in family members of patients with Celiac Disease. More than 97% of Celiac patients carry either HLA-DQ2. (DQA1*05/DQB1*02) or HLA-DQ8 (DQA1*03/DQB1*0302) or both. However, 39% of the general U.S. population carry these HLA-DQ variants, as a consequence, the presence of HLA-DQ2 or DQ8 or both variants is not per se diagnostic of Celiac Disease.
[34399Z]–34399 HLA Typing for Narcolepsy
(HLA-DR15 and DQB1*0602)
Differentiate between narcolepsy and other sleep disorders
16773 HLA-A29 DNA Typing Birdshot retinochoroidopathy (BSCR) is a rare posterior uveitis, characterized by distinctive, multiple, hypopigmented choroidal and retinal lesions. At least 96% of patients, if not all, share the major histocompatibility antigen, HLA-A29. However, most HLA-A29 positive individuals do not have this disease. Together with clinical manifestations, HLA-A29 typing is used for diagnosis of BSCR.

HLA-B51 DNA Typing

Behcet's disease (BD) is a chronic inflammatory disease, characterized by oral aphthous ulcers, genital ulcers, and skin lesions. Between 50-80% of BD patients are HLA-B51 positive.

[10951X]–10951 HLA-A Class I DNA Typing Determine susceptibility to certain diseases, especially HLA-associated autoimmune disease.
[10950X]–10950 HLA-B Class I DNA Typing
[15463X]–15463 HLA-C Class I DNA Typing
[10953X]–10953 HLA-DQB1 Class II DNA Typing
[10952X]–10952 HLA-DRB1 Class II DNA Typing


Test Code Test Name Clinical Application
[19774X]–19774 HLA-B*5701 Typing HLA-B*5701 has been shown in retrospective clinical studies to be associated with Abacavir hypersensitivity reaction (HSR) in HIV patients. In Abacavir-naive patients, HLA-B*5701 genotyping may be useful for risk stratification.
[40045X]–40045 HLA-B*1502 Typing Dangerous or even fatal skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with the HLA-B*1502 allele. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians. HLA-B*1502 genotyping may be useful for risk stratification.