Quest Diagnostics: Interpretive Guide

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Welcome to the Interpretive Guide. This Guide provides information relating to test selection, utilization, and interpretation. The Guide is continually updated by adding new information and modifying posted information. All information is based on peer-reviewed publications, practice guidelines, or other reputable sources and is intended to be without promotional considerations.

Reference ranges are provided for your convenience and are based on Quest Diagnostics data or published references (where cited). These ranges can serve as a guideline; however, interpretation of patient results should be based on the ranges provided in the patient report.

Included in the Interpretive Guide are four types of information:

•	Test highlights and summaries provide a review of clinical use and background, methodology, specimen requirements, and interpretation of the test.

•	Test guides provide testing algorithms or other information that assists in appropriate test selection.

•	Technology guides compare multiple technologies provided for the same or similar analytes.

•	Clinical focus pages focus on specific diseases or conditions, providing detailed information on what tests are available, how they are incorporated into clinical practice, and what the results mean.

What's New

•	The Lymphoid Neoplasms Test Guide describes tests available for the differential diagnosis of B-, T-, and natural killer-cell lymphoid neoplasms. Following diagnosis, laboratory test results are also useful to assess prognosis, select therapy, monitory therapeutic response, and detect relapse.
•	HE4 is a new marker that can be used for monitoring recurrence and disease progression in patients with epithelial ovarian cancer.
•	HLA Typing for Celiac Disease is useful to rule out celiac disease (CD) and genetic susceptibility for CD. The Test Summary defines individuals who may benefit from this testing including those at high risk of CD.
•	ImmunoCAP^®´ Specific IgE Blood Test is useful for diagnosis of IgE-mediated allergic disorders. In vitro tests such as the ImmunoCAP are preferred, relative to skin tests, in certain clinical circumstances.
•	The Onychomycosis Test Guide details the advantages, disadvantages, and diagnostic sensitivity of the various tests used in onychomycosis diagnosis.