HLA Test Menu

Click on test name for additional test-specific information.

Disease Detection
Test Code	Test Name	Clinical Application
15584Z	HLA-B27 DNA Typing	Confirm the diagnosis of ankylosing spondylitis and related spondyloarthropathies
17135X	HLA Typing for Celiac Disease (HLA-DQ2 and -DQ8)	Assess risk of celiac disease in symptomatic patients and in family members of patients with celiac disease
34399Z	HLA Typing for Narcolepsy (HLA-DR15 and -DQ6)	Differentiate between narcolepsy and other sleep disorders
10951X	HLA-A Class I DNA Typing	Determine susceptibility to certain diseases, especially HLA-associated autoimmune disease. Include suspected diagnosis and antigen(s)/allele(s) to be tested on the test requisition.
10950X	HLA-B Class I DNA Typing
15463X	HLA-C Class I DNA Typing
10953X	HLA-DQB1 Class II DNA Typing
10952X	HLA-DRB1 Class II DNA Typing
Hematopoietic Stem Cell/Bone Marrow Transplantation
Test Code	Test Name	Clinical Application
15484X	HLA Class I A, B, C DNA Typing	Initial HLA screen for transplant recipient and genetically related potential donor(s)
15485X	HLA Class II DR, DQ DNA Typing
17397X	HLA-A High Resolution SBT Typing†	Determine HLA type of transplant recipient and unrelated potential donor(s)Second-level testing for determining HLA type in transplant recipient and genetically related potential donor(s)
17396X	HLA-B High Resolution SBT Typing†
17395X	HLA-C High Resolution SBT Typing†
17393X	HLA-DRB1 High Resolution SBT Typing†
17394X	HLA-DQB1 High Resolution SBT Typing†
17398X	HLA-A2 Typing with Reflex to A2 High Resolution SBT Sub typing†‡
Platelet Transfusion
Test Code	Test Name	Clinical Application
15757X	HLA-A, B Class I DNA Typing	Identify HLA-compatible platelets to improve platelet survival after transfusion; platelet cross-matching and STAT services not provided
Solid Organ Transplantation
Test Code	Test Name	Clinical Application
15484X	HLA Class I A, B, C DNA Typing	Screen transplant recipient and potential donor(s) prior to enrollment in a transplant registry
15485X	HLA Class II DR, DQ DNA Typing
Vaccine/Immunotherapy Eligibility Assessment
Test Code	Test Name	Clinical Application
17398X	HLA-A2 Typing with Reflex to A2 High Resolution SBT Sub typing†‡	Assess eligibility for HLA-A2-dependent immunotherapy
17397X	HLA-A High Resolution SBT Typing†	Assess eligibility for HLA-A, -B or -C-dependent immunotherapy
17396X	HLA-B High Resolution SBT Typing†
17395X	HLA-C High Resolution SBT Typing†

SBT: Sequence-based typing

* The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

† This test was developed and its performance characteristics determined by Quest Diagnostics Nichols Institute. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

‡ Reflex tests are performed at an additional charge and are associated with an additional CPT code.

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